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Preventing Bacterial Biofilm Formation

From: "Stephen Millar" To: "Periotherapist group Sent: Wednesday, February 06, 2008 2:01 AM Subject: [periotherapist] Preventing Bacterial Biofilm Formation About Biosignal and the anti-biofilm technology Biosignalís anti-biofilm technology is based on a discovery that the eastern Australian seaweed Delisea pulchra produces natural furanones that disable bacteria's ability to colonise. The fundamental problem with existing anti-bacterials, including antibiotics, is bacterial resistance. Bacteria rapidly produce resistant strains when faced with strong selective pressure by killing agents or growth-inhibitory agents. Furanones lull bacteria to inaction and appear to avoid the problem of bacterial resistance. Biosignal produces synthetic compounds effective on inanimate surfaces such as pipes and membranes and animate surfaces such as lungs, skin and teeth. Biosignalís collaborations with US, European and Japanese companies are assessing new applications across a range of consumer and industrial products. ASX Announcement Biosignal compounds in dental material reduce bacteria by 99% US entrepreneurs fund University of Minnesota study 4th of February 2008, Sydney: Laboratory testing using Biosignal Ltdís (ASX: BOS) anti-bacterial compounds in dental material found Biosignalís compounds reduce bacteria by more than 99 percent. The material tested was a commercially used resin composite dental material commonly used to restore tooth decay. The work was commissioned and paid for by two entrepreneurial US- based oral care experts Dr Gary Jernberg and Dr Richard Simonsen. The pair has an agreement with Biosignal to assess commercial potential of Biosignalís compounds in selected oral care applications. The study, announced to the market in March 2007 when it was initiated, was conducted by the University of Minnesota, School of Dentistry which is internationally recognised as a leader in oral microbiology and prevention of oral disease including tooth decay and periodontal disease. This is a field in which there are no satisfactory products on the market, said Peter Steinberg, CEO of Biosignal. Our main competitors are traditional antibiotics, which are becoming increasingly compromised by super bugs resistant and highly dangerous bacteria. Biosignalís compounds work by stopping bacterial communication and preventing bacterial biofilm formation rather than killing bacteria. This technique is not aggressive and should minimise the problem of resistance while remaining effective. Importantly, Biosignal's compounds were covalently bound to the resin composite dental material with no measurable leaching from the composite. This should significantly reduce regulatory timelines at the US FDA or equivalent agencies. Biosignal owns all intellectual property arising from the project. Jernberg, Simonsen and Biosignal are commencing discussions to license the technology to leading dental product companies. Further animal and human trials are expected to be conducted in collaboration with a licensee. The bacterium tested was Streptococcus mutans which causes tooth decay. The concentration of Biosignalís compounds in the dental material ranged up to a maximum of 3 percent of the total mass. The testing also assessed impacts on the mechanical properties of the dental material. No adverse effects of any expected clinical significance were identified.
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