Check Page Ranking

Home
Dental tourism
Conferences
Dental books
Bad breath
Kids caries
Smoking effects
Patient info
Dental Videos
Wisdom tooth
Diabetes
Drugs of choice
Virtual dental expo

Endo tips    Better Endo    Endo abstracts    Endo discussions

Periodontitis - Bacterial infections

(click on the description to go the article) 1 A strategy for eradicating periodontal bacteria - Abstract 2 Pathogen and resistance spectrum in intraoral infections of the jaw-facial area with special reference to anaerobic bacteria - Abstract 3 Bacteroides, Prevotella, and Porphyromonas species: a review of antibiotic resistance and therapeutic options - Abstract 4 Metronidazole in periodontitis V: debridement should precede medication.
   Adjuvant antibiotic therapy as a 2-step treatment concept in early-onset    periodontitis: a strategy for eradication of bacteria that cause periodontitis....  TOP 
1 A strategy for eradicating periodontal bacteria - Abstract TITLE: [Adjuvant antibiotic therapy as a 2-step treatment concept in early-onset periodontitis: a strategy for eradication of bacteria that cause periodontitis] VERNACULAR TITLE: Adjuvante Antibiotikagabe in einem Zweischritt-Therapiekonzept f ur die fruh beginnende Parodontitis. Eine Strategie zur Eradikation parodontopathogener Bakterien. AUTHORS: Sigusch B; Pfister W; Klinger G; Glockmann E AUTHOR AFFILIATION: Poliklinik fur Konservierende Zahnheilkunde, Friedrich-Schiller-Universitat Jena. bernd.w.sigusch@med.uni-jena.de SOURCE: Dtsch Med Wochenschr 2000 Oct 6;125(40):1186-91. CITATION IDS: PMID: 11075250 UI: 20526386 ABSTRACT: BACKGROUND AND OBJECTIVE: The periodontal region is a source of gram-negative bacterial infection. The pathogens involved have recently also been demonstrated in atheromatous plaques. They may increase the risk of myocardial infarction. In this study a strategy for eradicating periodontal bacteria and thus healing in patients with periodontal pockets and advanced destruction of alveolar bone was examined. PATIENTS AND METHODS: Initial periodontal status was documented in 36 patients with periodontitis (24 women, 12 men) who were then randomly assigned to one of three groups. Those in two of the groups were given either metronidazole or doxycycline orally as adjuvant treatment, while the third group received no antibiotics. Patients in all groups were treated according to a two-step procedure. In step 1, extensive supra- and subgingival plaques and concrements were removed. In step 2, root debridement and/or closed curettage of all pockets was undertaken in one visit, and the antibiotic given to the patients in groups 1 and 2. Results were assessed 3 weeks after the first step and 6 months, 2 and 4 years after step 2. RESULTS: The initial examination at 3 weeks revealed significant changes in all three groups with regard to the incidence of plaque and sulcus bleeding, but not regarding probing depth and attachment level. However, there were significant changes in probing depth and attachment level in all groups after step 2. Periodontal attachment was significantly improved at 2 and 4 years in the patients on metronidazole, but not those on doxycycline or no antibiotics. The greatest decrease in bleeding tendency was recorded in the metronidazole group. This group also had the greatest gain of new alveolar bone compared with the other two groups. Complete eradication of Porphyromonas gingivalis and Actinobacillus (Hemophilus) actinomycetemcomitans, important pathogenic bacteria that may have an atherogenic action, was obtained only in patients on metronidazole. CONCLUSION: The tissue-sparing two-step procedure brought about good clinical and radiological results, which can be significantly bettered by the addition of metronidazole, achieving eradication of pathogens involved in periodontal disease. MAIN MESH HEADINGS: Antibiotics/*pharmacology Bacteria/*drug effects Periodontitis/*therapy Periodontium/*microbiology ADDITIONAL MESH HEADINGS: Administration, Oral Adolescence Adult Alveolar Bone Loss/drug therapy Alveolar Bone Loss/therapy Anti-Infective Agents/administration & dosage Antibiotics/administration & dosage Antibiotics, Tetracycline/administration & dosage Bacteria/isolation & purification Chemotherapy, Adjuvant Comparative Study Curettage Data Interpretation, Statistical Debridement Dental Plaque/therapy Doxycycline/administration & dosage Female Focal Infection, Dental/prevention & control Follow-Up Studies Human Male Metronidazole/administration & dosage Middle Age Periodontal Pocket/drug therapy Periodontal Pocket/therapy Periodontitis/drug therapy Periodontitis/microbiology Time Factors 2001/2 2001/28 10:1 PUBLICATION TYPES: Clinical Trial Journal Article Randomized Controlled Trial CAS REGISTRY NUMBERS: 0 (Anti-Infective Agents) 0 (Antibiotics) 0 (Antibiotics, Tetracycline) 443-48-1 (Metronidazole) 564-25-0 (Doxycycline) LANGUAGES: ger
   Pathogen and resistance spectrum in intraoral infections of the jaw-facial area    with special reference to anaerobic bacteria....  TOP 
2 Pathogen and resistance spectrum in intraoral infections of the jaw-facial area with special reference to anaerobic bacteria - Abstract TITLE: [Pathogen and resistance spectrum in intraoral infections of the jaw-facial area with special reference to anaerobic bacteria] VERNACULAR TITLE: Erreger- und Resistenzspektrum bei intraoralen Infektionen des Kiefer-Gesichts-Bereichs unter besonderer Berucksichtigung der anaeroben Keimflora. AUTHORS: Eick S; Pfister W; Korn-Stemme S; Magdefessel-Schmutzer U; Straube E AUTHOR AFFILIATION: Institut fur Medizinische Mikrobiologie, Friedrich-Schiller-Universitat Jena, Deutschland. SOURCE: Mund Kiefer Gesichtschir 2000 Jul;4(4):234-9. CITATION IDS: PMID: 10994323 UI: 20449776 ABSTRACT: The aim of the study was to obtain more knowledge about the aerobic and anaerobic species causing maxillofacial infections and their resistance patterns today. Samples of pus or infectious tissue obtained from 110 patients of maxillofacial surgery were investigated microbiologically by means of aerobic and anaerobic cultivation. After incubation, the cultivated species were isolated and identified. The resistance patterns of all bacteria to penicillin, doxycyclin, and clindamycin were determined. Additionally, the resistance of aerobic species to cefuroxim was documented, and the MICs of cefoxitin and metronidazole to the anaerobic species were assessed. The most frequent disease was periodontitis apicalis (70 patients). Aerobic species alone were found in 23% of the samples, 14% of the infections harbored only anaerobes, but 63% were mixed infections caused by aerobic and anaerobic bacteria. In case of detection of aerobic species, streptococci were always identified. Five patients were infected by Staphylococcus aureus and gram-negative aerobic rods were found in eight patients. Most of the anaerobic species were black pigmented prevotella species (62), nonpigmented prevotellae (56), and fusobacteria (37). Metronidazole and clindamycin were highly efficient to gram-negative anaerobic rods. Most of the oral species were resistant to penicillin and doxycyclin. The indication for applying antibiotics should always be noticed and these drugs should only be used after determination of the pathogenic microorganisms and their susceptibility to the antimicrobials. MAIN MESH HEADINGS: Bacterial Infections/*microbiology Odontogenic Cysts/*microbiology Periodontitis/*microbiology Surgical Wound Infection/*microbiology ADDITIONAL MESH HEADINGS: Bacteria, Aerobic/drug effects Bacteria, Aerobic/isolation & purification Bacteria, Anaerobic/drug effects Bacteria, Anaerobic/isolation & purification Bacterial Infections/drug therapy Bacteriological Techniques Dose-Response Relationship, Drug Human Microbial Sensitivity Tests Odontogenic Cysts/drug therapy Periodontitis/drug therapy Surgical Wound Infection/drug therapy 2001/2 2001/28 10:1 PUBLICATION TYPES: Journal Article LANGUAGES: ger
   Bacteroides, Prevotella, and Porphyromonas species: a review of antibiotic    resistance and therapeutic options...  TOP 
3 Bacteroides, Prevotella, and Porphyromonas species: a review of antibiotic resistance and therapeutic options. TITLE: Bacteroides, Prevotella, and Porphyromonas species: a review of antibiotic resistance and therapeutic options. AUTHORS: Falagas ME; Siakavellas E AUTHOR AFFILIATION: Hygeia Hospital, 4 Er. Stavrou Str., 151 23, Athens, Greece. falagas@ath.forthnet.gr SOURCE: Int J Antimicrob Agents 2000 Jun;15(1):1-9. CITATION IDS: PMID: 10856670 UI: 20316353 ABSTRACT: Recent basic and clinical research efforts have shed more light on the taxonomy, microbiology, epidemiology, antimicrobial susceptibility and treatment of Bacteroides, Prevotella, and Porphyromonas species. Of all anaerobic bacteria, Bacteroides is the most frequently isolated pathogen from clinical specimens, including blood. Bacteroides, Prevotella and/or Porphyromonas species have been isolated from clinical specimens in cases of infection from almost all anatomic sites. Several multicentre surveys have documented an alarming gradual increase of resistance rates of Bacteroides, Prevotella and Porphyromonas species worldwide. Antimicrobial agents active against >99% of clinical isolates of Bacteroides are metronidazole, chloramphenicol and carbapenems. Agents active against 95-99% of Bacteroides fragilis isolates are the beta-lactam/beta-lactamase inhibitor combinations. B. fragilis group species other than B. fragilis are more likely to be resistant to beta-lactam/beta-lactamase inhibitor combinations than B. fragilis. MAIN MESH HEADINGS: Anti-Infective Agents/*pharmacology Bacteroides/*drug effects Porphyromonas/*drug effects Prevotella/*drug effects ADDITIONAL MESH HEADINGS: Anti-Infective Agents/therapeutic use Bacterial Infections/drug therapy Drug Resistance, Microbial Human Microbial Sensitivity Tests 2000/09 2000/23 11:01 PUBLICATION TYPES: Journal Article Review Review, Tutorial CAS REGISTRY NUMBERS: 0 (Anti-Infective Agents) LANGUAGES: eng
   Metronidazole in periodontitis V: debridement should precede medication...  TOP 
4 Metronidazole in periodontitis V: debridement should precede medication. TITLE: Metronidazole in periodontitis V: debridement should precede medication. AUTHORS: Loesche WJ; Giordano JR AUTHOR AFFILIATION: University of Michigan, School of Dentistry, Ann Arbor. SOURCE: Compendium 1994 Oct;15(10):1198, 1201, 1203 passim; quiz 1218. CITATION IDS: PMID: 7987887 UI: 95079473 ABSTRACT: Two previous double-blind studies have shown that 1 week of metronidazole, plus scaling and root planing, can significantly reduce the number of teeth per patient that require periodontal surgery, when compared to a positive-control treatment that consisted of 1 week of placebo treatment plus scaling and root planing. The only difference between the two studies was that in one, metronidazole or placebo tablets were taken at the beginning of the debridement procedures, while in the other, the tablets were taken after all debridement was completed. This article describes the results obtained by combining the data from both studies and using an analysis of variance to identify the effects of medication and those of the study protocol. There was an average reduction in surgical needs of about 7.1 teeth per patient using metronidazole compared to 2.4 teeth in the positive-control group (P = 0.004). In the deep pockets, there was a significant protocol effect because there were additional improvements associated with using the medications after the debridement was completed. MAIN MESH HEADINGS: Metronidazole/*therapeutic use Periodontitis/*drug therapy *Root Planing ADDITIONAL MESH HEADINGS: Adult Analysis of Variance Bacteria, Anaerobic/isolation & purification Clinical Protocols Dental Plaque/microbiology Dental Scaling Double-Blind Method Human Periodontal Pocket/pathology Periodontitis/microbiology Periodontitis/therapy Spirochaetales/isolation & purification Support, U.S. Gov't, P.H.S. Treatment Outcome 1994/10 1994/01 PUBLICATION TYPES: Clinical Trial Journal Article Randomized Controlled Trial CAS REGISTRY NUMBERS: 443-48-1 (Metronidazole) LANGUAGES: eng GRANT/CONTRACT ID: DE-06030/DE/NIDCR
    TOP 

Nice curves in mesial canal

Apical periodontits

Type III dens case

5 canaled molar

necrosis periradicular..

Triple paste pulpectomy

Endo cases - Marcia

"C" shaped canal anatomy

Psycho molar

routine case

straight lingual

Doomed tooth

another molar

Tooth #36

Instrument removal

Tooth #27

Mark Dreyer cases

Troughing case

6 year recall

9 clinical cases

Flareup after best treatment

Fred Barnett cases

Cases by Marga Ree

Glenn Van As cases

Sashi Nallapati cases

Cases by Jorg

Terry Pannkuk cases

New dental products II

New dental products

Difficult retreatment

Canal anatomy 46

Freak case

huge lateral canal

Separate MB canal

Crown infraction

5 year recall

Palatal canals

TF retreatment

Fiber cone

Bio race cases