| Ribavarin + Interferon alpha 2a, Adefovir, and lamivudine are
antivirals used to treat what virus? |
|
| What interferon is licensed for tx of chronic hep b and c infections?
|
|
| T or F: Interferons are viral specific |
|
| What definition? Host encoded proteins produced in response to
viruses, synthetic nucleotides, and foreign cells |
|
| T or F: Hepatitis B encodes a reverse transcriptase. |
|
| What is responsible for effecting resolution of HBV infection by
elimination infected hepatocyte? |
|
| What is responsible for causing the symptoms in HBV infections? |
|
| ____ of patients w/ chronic HBV infection have continued liver
destruction, cirrhosis, liver failure or primary hepatocellular carcinoma;
_____ of patients have chronic passsive hepatitis and don't have as many
problems. |
|
| (Acute/Chronic) infection of HBV occurs in about 5-10% of the
population. |
|
| Fulminant hepatitis occurs in ___% of patients and may be ______. |
|
| T or F: HBV is characterized by a short incubation period. |
|
| Symptoms of HBV infection appear in about _____% of the patients |
|
| T or F: HBV can be asymptomatic (chronic) |
|
| Where does HBV virus replicate? |
|
| What is the major source of the infectious virus HBV? |
|
| A chronic infection (of HBV) can be distinguished by the continued
finding of __________, ___________, or both and a lack of detectable
___________ to these antigens. |
|
| (HBsAG/HBeAg) is the best correlate to the presence of infectious
virus (HBV). |
|
| Detection of both HBsAg and HBeAg in the blood indicates
_____________. |
|
| What is HbcAG? |
|
| What common antigen to the particles produced by HBV-infected cells
have on the envelope? |
|
| How many particles does an HBV-infected cell produce? |
|
| Which particles produced by HBV-infected cells are the infectious
particles? |
|
| What are the largest particles produced by the infected cells (from
HBV)? |
|
| What is the virion of HBV called? (national board question) |
|
| What virus? Genome in a relaxed circular partially duplexed DNA (3.2
kb), replicates in the nucleus, has an RNA intermediate, enveloped, tissue
tropism in the liver. |
) |
| Why was there a sudden peak in influenza resistance to rimantadine and
amantadine in 2003 (mainly in China)? |
|
| What does neuraminidase (NA) on influenza do? |
|
| What do the new drugs Zanamivir and Oseltavivir (tamiflu) do? |
|
| How does influenza develop resistance to antivirals? |
|
| How do antivirals work to inhibit flu infection? |
|
| What antivirals are used for influenza? |
|
| T or F: Bird virus and Human virus can mix genes (undergo
reassortment) |
|
| Why is the flu vaccine an educated guess? |
|
| T or F: Flu vaccine is perfect every time |
|
| What is the definition of epidemic? Pandemic? |
|
| Reassortment is a _______ shift, while mutational drift is a _________
shift. (occurs in influenza) |
|
| T or F: enzymes (HA and NA) in flu virus can undergo mutation. |
|
| T or F: antivirals are effective against influenza even after the RNA
has been released into the cell. |
|
| What are the steps (4) of infection and replication for influenza? |
|
| What is the part of the flu virus that makes it very distinct from
other viruses? |
|
| T or F: bacterial pneumonia can develop secondary to the flu |
|
| What causes the systemic symptoms of the flu? |
|
| Flu symptoms usually resolve within ___ to ____ days. |
|
| What is the incubation period for flu virus? |
|
| where does flu infection begin? |
|
| How is influenza transmitted? |
|
| In an average year about ____ to _____% of the population get the flu
|
|
| What is the target for influenza antivirals? |
|
| Which glycoproteins are present on the surface of Influenza virus? |
|
| What virus? Segmented negative strand RNA, Helical Symmetry, Enveloped
|
|
