| What are the most common leukemias? |
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| What are the two major types of leukemias? |
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| Flow cytometry and cluster of differentiation are lab procdures to
detect what? |
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| As a result of leukemia, what lab findings do you find in the
PERIPHERAL blood? |
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| What is the most common eventual cause of death in patients w/
leukemias? |
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| Why does anemia, recurrent infection and bleeding occur in leukemia, a
WBC disorder? |
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| T or F: most cases of luekemias are caused by HTLV-1. |
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| What clotting factor is congenitally deficient in Hemophilia A? |
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| Hemophilia A & B are what type of bleeding disorders? |
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| What are 2 anticoagulants that inhibit coagulation factor production?
|
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| DIC is responsible for what clotting factor disease? |
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| What does the anticoagulant coumadin do? |
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| Why is chronic liver disease also known as hypofibrinogenemia |
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| Why does chronic liver disease cause inadequate production of clotting
factors? |
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| ________ clotting factor deficiencies are caused by inadequte
production, excessive consumption, inhibition by anticoagulants. |
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| Aspirin, NSAIDS, ESRD (accumulation of metabolites) and Plavix all
lead to ___________ |
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| Two forms of Qualitative platelet bleeding disorders: |
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| DIC (yes, that's right), (Shock, infection tumors, injured endothelial
cells, activation of coagulation system, widespread thrombi, fibrinolysis,
bleeding) all contribute to __________. |
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| Hypersplenism leads to _____________. |
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| Autoimmune destruction, SLE, HIV,Heparin-induced thrombocytopenia, all
contribute to _________. |
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| Aplastic anemia, leukemia, infecious agents (ie rubella), and drugs
(interfere w/ megakaryocytes) are contributory to ______________. |
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| The etiology of this disease is: Decreased production of platelets,
Increased loss of platelets |
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| Petechiae, and ecchymoses (skin+mucous membranes) are signs of what
bleeding disorder? |
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| What occurs when platelet levels reach below 20,000/mm3? |
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| What platelet level characterizes thrombocytopenia? |
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| This type of bleeding disorder can be qualitative or quantitative |
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| What bleeding disorder? Petechiae & eccymoses, skin, mucous
membranes, after minor trauma/spontaneously; normal platelet count, PT
& PTT bleeding time |
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| What bleeding disorder? Autoimmune vasculitidies, allergic drugs rxns.
|
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| Scurvy, Amyloid, chronic systemic steroid use, inherited conditions
infectious causes, and aging can all cause what type of bleeding disorder?
|
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| What are 3 mechanisms of vascular bleeding disorders? |
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| What is the international normalized ratio (INR)? |
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| Increased PTT is shown with a defect of factors
__,___,___,___,___,___,prothrombin, fibrinogen or acquired antibody that
interferes with intrinsic pathway. |
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| Assesses the integrity of the INTRINSIC and common clotting pathways
|
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| What lab evaluation? Time required for plasma to clot |
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| Deficiency of factors V, VII, or X, prothrombin, or fibrinogen is a
diagnosis of ____________ Prothrombin time (PT) |
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| What lab evaluation? Tests adequacy of Extrinsic and common
coagulation pathways |
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| What lab evaluation? Time needed for plasma to clot in presence of
exogenous source of thromboplastin and calcium |
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| What is the normal platelet count? |
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| Which laboratory evaluation? In vivo assessment of platelet response
to vascular injury, normal=several minutes, elevated=defect in platelet #
or function |
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| What disease? Bone destruction, punched out radiolucencies, soft
tissue lesions, children. |
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| What other variants of Multiple myeloma are there? |
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| What disease? Lab findings: monoclonal Ig spike, Bence-Jones Protein,
Abnormal plasma cells, amyloid deposition, light chain proteinuria |
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| What disease? Bone pain & destruction, hypercalcemia, metastatic
calcification, renal damage, bone fractures |
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| What disease? Adults (45-50 yrs), NOT in children, bone destruction,
punched out radiolucencies |
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| What WBC disorder involves malignant plasma cells? |
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| T or F: bone marrow biopsy must be performed to confirm diagnosis of
leukemia |
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| Desmopressin, factor VIII, XI concentrates are used in hospital based
Tx for patients with _____________ |
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| For warfarin patients, INR must be below __________for minor surgeries
|
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| ________ heparin patients must be hospitalized for Tx, while
__________ heparin patients are generally not a concern |
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| T or F: Plavix is a concern for inc. bleeding during Tx |
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